Abstract: This study innovatively applies the RGB (Red, Green, Blue) detection method to analytical chemistry teaching experiments. Utilizing our self-developed Color Picker software to monitor RGB value variations during the titration process, we established an analytical approach for endpoint determination based on second-order differential changes in the G/(R+G+B) ratio. When implemented in the “Standardization of Hydrochloric Acid Solution with Anhydrous Sodium Carbonate” experiment, the method demonstrated endpoint errors below 0.1%, with a relative standard deviation of 0.084% across triplicate measurements. Compared with conventional visual titration, this technique exhibits superior accuracy and reproducibility while providing accessibility for color vision-deficient students. The experiment not only fosters students’ rigorous scientific approach but also stimulates innovative thinking, enhancing their practical understanding of chemical experimentation.

Key words: Acid-base titration, Visualization, RGB detection, Second-order differential values, Endpoint error