Abstract: The Minisci reaction is an efficient method for synthesizing alkyl-substituted N-heteroarenes, involving the addition of alkyl radicals to N-heteroarenes under acidic and oxidative conditions. In this study, 1-benzyl isoquinoline was synthesized through the Minisci reaction using benzyl trimethylsilane as the alkyl radical precursor, ammonium persulfate ((NH₄)₂S₂O₈) as the oxidant, and dimethyl sulfoxide (DMSO) as the solvent. This experiment serves as a research-based laboratory exercise for junior undergraduates at our university, aiming to enhance students' scientific research and experimental operation skills, and stimulate innovative thinking.

Key words: Benzyl trimethylsilane, Isoquinoline, Minisci reaction, Teaching experiment