University Chemistry ›› 2026, Vol. 41 ›› Issue (7): 266-273.doi: 10.12461/PKU.DXHX202505015

• Chemistry Laboratory • Previous Articles    

Green synthesis of pyrrolo[1,2-a]quinoxaline derivatives as antineoplastic agents: a comprehensive chemistry laboratory teaching exploration

Huiru Sheng1, Rui Qi1, Chao Shen1, Hao Xu1, Jiabin Shen1, Pengfei Zhang2   

  1. 1 Basic Chemistry and Biology Experiments Teaching Center of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Province, China;
    2 Experimental Chemistry Teaching Center of Zhejiang Province, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China
  • Received:2025-05-08 Accepted:2025-07-29 Published:2026-06-27
  • Contact: Jiabin Shen, Pengfei Zhang E-mail:shenjiabinhznu@163.com;pfzhang@hznu.edu.cn

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Abstract: This study focuses on the molecular framework of pyrrolo[1,2-a]quinoxaline, known for its antitumor activity. Utilizing nitric acid and hydrochloric acid as chlorine gas precursors, we achieved a one-step synthesis of pyrrolo[1,2-a]quinoxaline antitumor agents through visible-light-catalyzed ring-opening and ring-closing reactions of arylcyclopropanes. By integrating fundamental organic chemistry principles with cutting-edge research topics, this experiment effectively enhances students’ comprehensive skills and innovative capabilities, making it particularly suitable as an advanced “comprehensive chemistry experiment” course for chemistry majors.

Key words: Ring-opening reaction, Ring-closing reaction, Pyrrolo[1,2-a]quinoxaline, Photocatalysis, Homogeneous catalysis