烯烃1,3-双官能团化反应研究进展

doi:10.12461/PKU.DXHX202507121

Abstract

Abstract: The 1,3-difunctionalization of alkenes offers an efficient synthetic strategy for constructing complex molecules through simultaneous introduction of two functional groups at non-adjacent carbon positions (α and γ). This transformation presents several challenges, including multiple potential reaction sites, extended distance between reactive centers, regioselective competition with 1,2- and 1,1-difunctionalized products, as well as chemoselectivity issues in multicomponent reactions. Developing catalytic systems that enable highly regioselective, step-economical, and atom-economical 1,3-difunctionalization of alkenes has become a key research focus in organic chemistry. This review summarizes recent advances in alkene 1,3-difunctionalization reactions and provides perspectives on future developments in this field.

Key words: Alkenes, 1,3-Difunctionalization, Regioselectivity, Research progress

Junyuan Zhang, Xiangzheng Ren, Zhiwei Miao. Research progress on 1,3-difunctionalization of alkenes[J].University Chemistry, 2026, 41(8): 148-161.

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Research progress on 1,3-difunctionalization of alkenes

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