Abstract: From the perspective of chemometrics, this study employs the titration of HCl with NaOH as an example to integrate three teaching modules: plotting titration curves, selecting indicators, and calculating endpoint errors. The designed problem-driven teaching approach follows this sequence: first posing the question of endpoint determination after curve plotting, then examining measurement accuracy concepts and indicator selection principles, and finally computing endpoint errors for different indicators based on proton conservation principles. This methodology aids students in constructing an accuracy-centered analytical chemistry framework while enhancing scientific reasoning skills. Additionally, it serves as a foundational template for instructors to adapt to other titration analysis teaching scenarios.

Key words: Accurate measurement, Acid-base titration, Problem-driven, Teaching design