铜催化的自由基C(sp3)-C(sp3)交叉偶联反应

doi:10.12461/PKU.DXHX202604064

Abstract

Abstract: Copper-catalyzed C(sp³)-C(sp³) cross-coupling reactions represent a vital approach for constructing saturated aliphatic frameworks. However, these reactions face significant challenges, including high activation energy barriers, undesirable side reactions involving alkyl radicals, and difficulties in controlling stereoselectivity. In recent years, researchers have developed a range of efficient strategies to overcome these obstacles. This review systematically summarizes the latest progress in this field, with a focus on reaction mechanisms, selectivity regulation, and synthetic applications, and offers perspectives on future directions.

Key words: Copper catalysis, Alkyl electrophiles, Radical, C(sp³)-C(sp³) Cross-coupling

Xiaoyang Dong, Zhongliang Li, Xinyuan Liu. Copper catalyzed radical C(sp³)-C(sp³) cross-coupling reactions[J].University Chemistry, 2026, (): 2604064.

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Copper catalyzed radical C(sp³)-C(sp³) cross-coupling reactions

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Copper catalyzed radical C(sp3)-C(sp3) cross-coupling reactions

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Copper catalyzed radical C(sp³)-C(sp³) cross-coupling reactions