Abstract: Chiral molecules are widely utilized in pharmaceuticals, agrochemicals, and related fields, and thus their highly selective synthesis represents a central research focus in organic chemistry. Metal-catalyzed asymmetric reactions offer an efficient route to such enantiopure compounds; however, conventional singleligand catalytic systems often face challenges, including intricate ligand synthesis and a trade-off between reaction selectivity and yield. Dynamic dual-ligand relay catalysis, which leverages the synergistic relay of two distinct ligands within a single catalytic cycle, enables flexible modulation of both reactivity and stereoselectivity, thereby offering a novel strategy for metal-catalyzed asymmetric transformations. This review systematically outlines the development of this field, with an emphasis on the mechanistic underpinnings and representative reactions of palladium-catalyzed asymmetric processes enabled by dynamic dual-ligand relay. It also examines recent advances and application prospects, aiming to reinforce students’ understanding of fundamental organometallic elementary reactions, broaden their awareness of cutting-edge research, and enrich their overall knowledge framework of organic chemistry.

Key words: Asymmetric catalysis, Palladium catalysis, Dual-ligand system, Dynamic dual-ligand relay, Ligand exchange