冷冻电镜技术应用于生物分子高分辨结构解析——2017年诺贝尔化学奖浅谈

doi:10.3866/PKU.DXHX201711035

Abstract

Abstract:

The 2017 Nobel Prize in chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for their contribution to developing the cryo-electron microscopy (cryo-EM) method for high-resolution structure determination of biomolecules in solution. In recent years, cryo-EM is leading a revolution in structural biology, and becoming a major tool in studying the structure and function of biomolecular machines. Here, we briefly describe the method development of cryo-EM and the personal contributions of the three Nobel Laureates.

Key words: Cryo-electron microscopy, Biomolecules, Structural biology, Nobel Prize in chemistry

Zhifei LI,Ning GAO. Cryo-EM Method for High-Resolution Structure Determination: A Brief Introduction to 2017 Nobel Prize in Chemistry[J].University Chemistry, 2018, 33(1): 1-6.

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Cryo-EM Method for High-Resolution Structure Determination: A Brief Introduction to 2017 Nobel Prize in Chemistry

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