综合化学实验：Fascaplysin类生物碱的命名、合成及表征

doi:10.3866/PKU.DXHX202210005

Abstract

Abstract:

We introduce a comprehensive chemistry experiment, namely "Nomenclature, synthesis, and characterization of fascaplysin alkaloids". The experiment involves the nomenclature, preparation, separation, purification, and characterization of fused-ring fascaplysin alkaloids. During the experiment, frontier scientific tools, especially the I₂/DMSO combination reagent system, were used to synthesize natural products such as fascaplysin alkaloids starting from aryl ketones to realize green organic chemical synthesis experiments. This approach deepens the understanding of fused ring compounds, stimulates independent thinking and innovation consciousness in students, and could be conducive for cultivating application-oriented talents in emerging engineering.

Key words: Green organic synthesis, Comprehensive chemistry experiment, Fascaplysin Alkloids, I₂/DMSO system

Aidang Lu, Ruihu Wang, Yunting Liu, Yanjun Jiang. Comprehensive Chemistry Experiment: Nomenclature, Synthesis, and Characterization of Fascaplysin Alkaloids[J].University Chemistry, 2023, 38(9): 141-147.

Figures/Tables 6

References 17

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引导性问题	设计目标
目前文献报道生物碱Fascaplysin的合成方法有哪些？介绍其中一种合成方法并与该实验方案进行比较	通过检索和阅读文献，训练学生文献阅读和总结的能力，并引出绿色有机合成的理念；重点学习I₂/DMSO组合体系作为工具化试剂在有机合成中的应用
生物碱Fascaplysin的化学名称是如何确定的？	学习并环化合物的命名规则
实验操作过程中有哪些注意事项？	巩固加热反应、抽滤等基本操作，练习封管反应实验操作
结合文献报道，利用哪些方法对生物碱Fascaplysin的结构进行表征确认？	学习并掌握利用核磁共振(NMR)和高分辨质谱(HRMS)对化合物进行表征，熟练运用核磁共振数据处理软件及解析

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Comprehensive Chemistry Experiment: Nomenclature, Synthesis, and Characterization of Fascaplysin Alkaloids

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