研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

doi:10.3866/PKU.DXHX202305088

University Chemistry ›› 2024, Vol. 39 ›› Issue (1): 134-141.doi: 10.3866/PKU.DXHX202305088

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Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of "Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment"

Guoliang Hu², Xinhao Yan², Ruixi Chen², Hongyu Liu¹^,²^,*(), Qizhi Yao¹^,², Jiao Li¹^,², Lingling Li¹^,²

¹ National Demonstration Center for Experimental Chemistry Education (University of Science and Technology of China), Hefei 230026, China
² School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China

Received:2023-05-31 Accepted:2023-06-29 Published:2023-07-13
Contact: Hongyu Liu E-mail:liuhyhx@ustc.edu.cn

Abstract

Abstract:

The "Alginate microcapsule preparation, drug encapsulation, and sustained controlled release analysis experiment" serves as a prominent research-oriented experiment within Type Ⅱ analytical chemistry experiments. It encompasses essential training in basic scientific research skills, including the exploration of microcapsule formation principles, experimental condition design, and microcapsule performance characterization. In this experiment, a mixed solution of sodium alginate and methylene blue was dropped into 3% CaCl₂ solution and 1% chitosan solution, respectively, resulting in the preparation of two microcapsules with distinct properties. The concentration of the solution was measured at various time intervals using spectrophotometry to derive sustained-release curves, facilitating a comparative analysis of the sustained-release properties of the two microcapsules. Additionally, a subsequent exploration experiment employed both one-step and two-step methods for microcapsule preparation, combining the advantages of both systems to achieve microcapsules with optimal sustained-release and stability characteristics.

Key words: Alginate, Microcapsule, Sustained-release curve, One-step method, Two-step method

Guoliang Hu, Xinhao Yan, Ruixi Chen, Hongyu Liu, Qizhi Yao, Jiao Li, Lingling Li. Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of "Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment"[J].University Chemistry, 2024, 39(1): 134-141.

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References 7

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t/min	0	15	30	45	60	75	90	105
A	0	0.390	0.454	0.493	0.504	0.510	0.515	0.517

t/min	0	15	30	45	60
A	0.138	0.324	0.448	0.520	0.554

t/min	0	15	30	45	60	75	90	105	120
A	0.363	0.707	0.813	0.839	0.933	0.968	1.003	0.995	0.999

t/min	1	8	12	20	30	44	60	76	85
A	0.105	0.311	0.374	0.406	0.471	0.534	0.582	0.610	0.621
t/min	95	109	120	138	145	150	155	167
A	0.631	0.641	0.645	0.651	0.656	0.659	0.663	0.663

t/min	0	5	9	25	38	49	57	67	78	89	100
A	0.675	0.809	1.022	1.127	1.177	1.218	1.244	1.272	1.287	1.307	1.314

Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of "Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment"

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t/min	0	15	30	45	60	75	90
A	0.100	0.452	0.589	0.652	0.700	0.729	0.727