University Chemistry ›› 2021, Vol. 36 ›› Issue (2): 2002045.doi: 10.3866/PKU.DXHX202002045

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Improvement of the Determination of Components in Paracetamol, Aminophenazone, Caffeine and Chlorpheniramine Maleate Tablet Using 1H Nuclear Magnetic Resonance Spectroscopy

Wenxue Chen(), Shasha Liu, Huixiang Li   

  • Received:2020-02-20 Accepted:2020-03-30 Published:2020-04-09
  • Contact: Wenxue Chen


The quantitative analysis based on nuclear magnetic resonance (NMR) spectroscopy has been widely applied to medical researches. In order to help students to learn more about the basic working principle of NMR spectrometer and the method of quantitative analysis of the drugs using NMR spectroscopy, two improvements were made about "the determination of components in paracetamol, aminophenazone, caffeine and chlorpheniramine maleate tablet using 1H NMR spectroscopy" experimentby optimizing the procedure for sample treatment and introducing the determination of the trace component (e.g., chlorpheniramine maleate) in the tablets. the content of four components in tablets could be simultaneously analyzed under mild conditions.

Key words: Nuclear magnetic resonance (NMR), Quantitative analysis, Paracetamol, aminophenazone, caffeine and chlorpheniramine maleate tablet (PACC)