无机纳米佐剂的设计及其在人类冠状病毒疫苗免疫增效中的应用

doi:10.3866/PKU.DXHX202201049

Abstract

Abstract:

In recent years, the emergence and spread of human coronavirus has brought serious crises and great challenges to the global public health system. Therefore, there is an urgent need to develop a broad-spectrum vaccine against coronavirus. Vaccine has two functions: antigen delivery and immune regulation. In most cases, the pure antigen cannot induce robust immune response to fight against infections. Vaccine adjuvant is an exogenous immunostimulatory added to vaccine and is a critical part in immunity shaping and antigen delivery. With the increasing knowledge of metalloimmunology, in addition to traditional aluminum-contained vaccine adjuvant, other kinds of inorganic adjuvants have attracted much attention for their unique immunological characteristics. Herein, several typical inorganic nanoparticles and their applications in coronavirus vaccines are introduced. The review aims to provide ideas for the development of personalized vaccines and new inorganic nanoadjuvants in the future.

Key words: Inorganic nanoadjuvant, Coronavirus, Vaccine

Susu Gao, Xin Wang, Yaling Wang, Chunying Chen. Design and Application of Inorganic Nanoadjuvant in Immunostimulation of Human Coronavirus Vaccine[J].University Chemistry, 2022, 37(3): 2201049.

Figures/Tables 9

References 54

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Design and Application of Inorganic Nanoadjuvant in Immunostimulation of Human Coronavirus Vaccine

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