Abstract: The “L-proline-catalyzed asymmetric Aldol condensation reaction” experiment constitutes a key component of the chiral synthesis module within the Synthetic Chemistry Laboratory Course of the Chemistry “101 Plan”, specifically designed to demonstrate principles of asymmetric catalytic synthesis. This experiment introduces the cutting-edge research area of organocatalytic asymmetric synthesis into undergraduate laboratory education, drawing inspiration from a work reported in 2000 by Benjamin List, who was awarded the 2021 Nobel Prize in Chemistry. This article comprehensively details the experimental design and implementation process. Through carefully structured pedagogy, the experiment enables students to master fundamental knowledge and techniques while fostering an understanding of scientific discovery processes, cultivating investigative skills and innovative thinking, stimulating research interests, and ultimately enhancing the quality of foundational chemistry education.

Key words: Chemistry “101 plan”, Synthetic chemistry laboratory, Course construction, Instructional design, Asymmetric catalysis, Nobel Prize in Chemistry