吉妥单抗复兴史

doi:10.3866/PKU.DXHX202206066

Abstract

Abstract:

This study describes the history of the development of antibody-drug conjugate in the form of interviews. The recognized history of the first commercially available antibody-drug conjugate "getuzumab" was used as the open line, whereas the progress of targeted drugs in chemical molecular design and analysis and detection was used as the dark line. The chemical structure, design, analysis, and development prospects of antibody-drug conjugates were comprehensively introduced.

Key words: Antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (Mylotarg), Targeted therapy, Antibody drug ratio (DAR), Size exclusion chromatography (SEC), Hydrophobic interaction chromatography (HIC)

Yi Wu, Rui Liu, Yi Lv. Renaissance of Gemtuzumab Ozogamicin[J].University Chemistry, 2022, 37(9): 2206066.

Figures/Tables 7

References 22

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Renaissance of Gemtuzumab Ozogamicin

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