Abstract:

The synthesis of 7-ethyl Camptothecin, an intermediate of the anticancer drug irinotecan, involves the alkylation reaction of heterocyclic aromatic hydrocarbons. This case study creatively integrates ideological and political education into the experimental process, linking it with the synthesis of pharmaceuticals and the concept of "Healthy China". The entire faculty and students undergo comprehensive ideological and political education throughout the process of case introduction, discussion, implementation, reflection, and assessment, addressing the issue of experimental courses focusing solely on experimental content while neglecting ideological and political education. This approach achieves the goal of holistic education. Throughout this process, it not only stimulates students' interest in learning, but also effectively trains them in scientific and innovative thinking, cultivating their spirit of exploration and awareness of innovation. Furthermore, it strengthens students' awareness of green chemistry, environmental protection, and sustainable development, enhancing their sense of responsibility and mission to contribute to a Healthy China. It also reinforces students' determination and confidence in applying their learned professional knowledge to serve the country.

Key words: Aromatic heterocycle, Alkylation, Green chemistry, Ideological and political education