天然多肽的电化学修饰

doi:10.12461/PKU.DXHX202406089

Abstract

Abstract: The rapid development of peptide therapeutics has sparked interest in the chemical modification of native peptides. Electrochemical modification has emerged as a promising technique, offering distinct advantages over traditional chemical approaches, including mild reaction conditions, high chemo-selectivity, and high atom efficiency, all of which align with the principles of green chemistry. This approach has found widespread applications in organic synthesis, with significant progress observed in recent years regarding its use in the modification of native peptides. In this review, we introduce the latest advancements in the field of electrochemical modifications of native peptides, focusing on experimental protocols, reaction mechanisms and synthetic applications.

Key words: Peptide, Electrochemistry, Green chemistry, Reaction mechanism

Zihan Lin, Wanzhen Lin, Fa-Jie Chen. Electrochemical Modifications of Native Peptides[J].University Chemistry, 2025, 40(3): 318-327.

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Electrochemical Modifications of Native Peptides

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