University Chemistry ›› 2026, Vol. 41 ›› Issue (9): 449-456.doi: 10.12461/PKU.DXHX202509025

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Spontaneous urea formation in microscale water droplets: an analysis of macro- and micro-chemical equilibrium

Ziyue Zhou1, Ruoxuan Wang2, Qun Wang1, Yang Li1, Xinzhi Wang1, Songtao Lu1, Xiaohong Wu1   

  1. 1 Department of Material Chemistry, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang Province, China;
    2 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, China
  • Received:2025-09-07 Accepted:2025-11-17 Published:2026-09-01
  • Contact: Qun Wang E-mail:wangqun5992@hit.edu.cn

Abstract: Chemical equilibrium represents a cornerstone concept in chemistry education, serving as a pivotal framework for cultivating students' understanding of dynamic systems and equilibrium principles. Within physical chemistry pedagogy, chemical equilibrium is traditionally approached as a macroscopic thermodynamic system, often neglecting microscopic interpretations. This pedagogical gap leaves students struggling to comprehend key microscopic characteristics of equilibrium states—particularly their dynamic and reversible nature. The “macro identification and micro analysis” competency embodies chemistry-specific cognitive approaches and constitutes a fundamental element of disciplinary core literacy. Contemporary educators are addressing this by integrating cutting-edge research into curricula, using landmark developments like synthetic urea formation as case studies to demonstrate advances in chemical equilibrium understanding. This methodology emphasizes interdisciplinary synthesis and knowledge application, fostering micro-level conceptual mastery while guiding students toward research-oriented disciplinary perspectives. Through this approach, students gain appreciation for how multidisciplinary knowledge informs practical applications, thereby facilitating the transformation of abstract concepts into scientific literacy.

Key words: Chemical equilibrium, Physical chemistry, Teaching philosophy, Macro-micro perspective