Abstract: ¹³C nuclear magnetic resonance (NMR) spectroscopy stands as one of the most fundamental techniques for structural elucidation of organic compounds. However, current NMR pedagogy often provides insufficient and fragmented coverage regarding spectral interpretation of fluorine-containing compounds. This educational gap leads both chemistry students and specialized organic chemistry researchers to frequently neglect the significant impact of ¹⁹F-¹³C spin-spin coupling on carbon signal splitting patterns, potentially resulting in misinterpretation of ¹³C NMR spectra. The present work systematically examines the coupling interactions between ¹⁹F and ¹³C nuclei in NMR spectroscopy, supported by detailed analyses of representative ¹³C NMR spectra from authentic research cases involving typical organofluorine compounds. Through this approach, we aim to establish comprehensive guidelines for recognizing characteristic ¹⁹F-¹³C coupling patterns, thereby providing essential references and practical analytical methodologies for structural characterization of fluorinated organic compounds.

Key words: Fluorinated organic compounds, ¹³C NMR spectra, Spin coupling, Coupling constant