大学化学 >> 2021, Vol. 36 >> Issue (9): 2107008.doi: 10.3866/PKU.DXHX202107008

所属专题： 分析化学课程与实验教学

师生笔谈 上一篇    下一篇

检出限与灵敏度关系及影响因素的探讨

漆红兰(), 李佳妮, 张成孝()   

  • 收稿日期:2021-06-30 录用日期:2021-07-28 发布日期:2021-08-19
  • 通讯作者: 漆红兰,张成孝 E-mail:honglanqi@snnu.edu.cn;cxzhang@snnu.edu.cn
  • 作者简介:Email: cxzhang@snnu.edu.cn (张成孝)
    Email: honglanqi@snnu.edu.cn (漆红兰)
  • 基金资助:
    国家自然科学基金(21775097);国家自然科学基金(21775097);2017陕西师范大学名师工作室项目

Discussion on the Relationship and Influence Factors of the Limit of Detection and the Sensitivity of Analytical Methods

Honglan Qi(), Jiani Li, Chengxiao Zhang()   

  • Received:2021-06-30 Accepted:2021-07-28 Published:2021-08-19
  • Contact: Honglan Qi,Chengxiao Zhang E-mail:honglanqi@snnu.edu.cn;cxzhang@snnu.edu.cn

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摘要：

检出限和灵敏度是评价分析方法的两个重要指标。国际纯粹与应用化学联合会（IUPAC）等对检出限和灵敏度的定义给出了明确的推荐。但是，有些教材和学术论文中检出限和灵敏度的使用仍然较为混乱。本文归纳了检出限和灵敏度的定义和计算方法，讨论了现代分析方法检出限和灵敏度的影响因素，提出了降低检出限和提高灵敏度的一些策略。

关键词: 检出限, 灵敏度, 标准曲线, 分析化学

Abstract:

The Limit of Detection and Sensitivity of analytical methods are two basic parameters for evaluating analytical methods. The International Union of Pure and Applied Chemistry (IUPAC) clearly recommends their definitions. However, both of them are still somewhat confused in some textbooks and research papers of analytical chemistry. Here, the definitions of both Limit of Detection and Sensitivity are clearly presented and the influence factors on Limit of Detection and Sensitivity of modern analytical methods are discussed. Some strategies to improve the Limit of Detection and the Sensitivity are proposed.

Key words: Limit of Detection, Sensitivity, Standard curve, Analytical chemistry