研教融合型药学基础化学教学案例库的构建与思考

doi:10.12461/PKU.DXHX202507079

摘要/Abstract

摘要： 围绕“研教融合”理念，系统阐述了药学基础化学(无机化学)教学案例库的构建路径与实践经验。案例库以“前沿成果-基础原理-药学场景”三向贯通为核心，精选Nature、Science、Cell等顶级期刊成果，转化为可教学的典型案例，涵盖分子结构、配位化学、氧化还原、元素化学等知识点。案例设计突出“临床问题-药学前沿-中药专题-生命科学发现”四条主线，强化学生从分子层面理解药物机制与研发实践的能力。

关键词: 研教融合, 无机化学, 药学教育, 教学案例库

Abstract: This paper conducts a systematic elaboration on the development and implementation of a teaching case database for pharmaceutical basic chemistry (inorganic chemistry) within the framework of “research-education integration”. The database is characterized by a tripartite structure that connects “cutting-edge research findings-fundamental principles-pharmaceutical applications”. The case studies included in the database are carefully selected from top-tier journals such as Nature, Science, and Cell. These cases encompass key chemical concepts like molecular structures, coordination chemistry, redox reactions, and elemental chemistry. The design of the database emphasizes four thematic dimensions: clinical challenges, pharmaceutical innovations, traditional Chinese medicine applications, and life science discoveries, which enhances students' ability to understand drug mechanisms and development processes at the molecular level.

Key words: Research-education integration, Inorganic chemistry, Pharmaceutical education, Teaching case database

展鹏. 研教融合型药学基础化学教学案例库的构建与思考[J]. 大学化学, 2026, 41(8): 130-138.

Peng Zhan. Construction and reflection on a research-education integrated teaching case database for pharmaceutical basic chemistry[J]. University Chemistry, 2026, 41(8): 130-138.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202507079

https://www.dxhx.pku.edu.cn/CN/Y2026/V41/I8/130

参考文献

[1] 朱亚先, 周立亚, 匡勤, 王凡, 王颖霞, 郑兰荪. 大学化学, 2022, 37(11), 2205037.
[2] 匡勤, 郑兰荪, 朱亚先. 大学化学, 2024, 39(10), 14.
[3] 蔡苹, 朱亚先, 胡涛. 大学化学, 2024, 39(10), 84.
[4] 鹿现永, 胡涛. 大学化学, 2025, 40(7), 127.
[5] 展鹏, 刘新泳. 大学化学, 2023, 38(12), 10.
[6] 展鹏. 大学化学, 2023, 38(12), 1.
[7] 展鹏, 刘新泳. 大学化学, 2022, 37(11), 2202034.
[8] 展鹏, 蒋小飞, 王艺铭, 兰共德, 刘新泳. 大学化学, 2019, 34(11), 61.
[9] T. Shimajiri, S. Kawaguchi, T. Suzuki, Y. Ishigaki, Nature 2024, 634(8033), 347.
[10] S.E. Wheeler, J. Am. Chem. Soc. 2025, 147(23), 19738.
[11] 超越“氢键”, 全新定义! [2025-08-21]. https://mp.weixin.qq.com/s/DT11j64KFUyeFFwnAzPnEQ
[12] S. Borkar, P. Baumli, T. Vance, E. Sharma, X. Shi, J.Y. Wu, G. Yao, D. Myung, G.G. Fuller, Proc. Natl. Acad. Sci. U. S. A. 2024, 121(31), e2407501121.
[13] Q. Tan, Y. Zhu, J. Li, Z. Chen, G.W. Han, I. Kufareva, T. Li, L. Ma, G. Fenalti, J. Li, et al., Science 2013, 341(6152), 1387.
[14] Z. Han, J. Li, Q. Liao, R. Luo, L. Wu, Y. Shi, L. Zhou, Q. Zhang, M. Erdélyi, W. Zhu, et al., J. Med. Chem. 2025, 68(9), 9537.
[15] J. Velcicky, E. Ngo, M.R. Bauer, A. Meyer, A. Schlapbach, S. Racine, D. Orain, D. Pflieger, S. Teixeira-Fouchard, C. Dubois, et al., ChemMedChem 2025, 20(7), e202400851.
[16] M.H. Daniels, J. Castro, Y.T. Lee, D. Gotur, K.E. Knockenhauer, S. Grigoriu, G.J. Lockbaum, J.E. Cheong, C. Lu, D. Brennan, et al., J. Med. Chem. 2025, 68(9), 9537.
[17] D.E. Heppner, J. Med. Chem. 2025, 68(5), 4991.
[18] S. Duan, M. Hua, C.W. Zhang, W. Hong, Y. Yan, A. Jazzar, C. Chen, P. Shi, M. Si, D. Wu, et al., Chem. Rev. 2025, 125(12), 1.
[19] Y. Zhou, H. Ye, Y. Yu, C. Ge, M. Yin, Z. Liu, J. Shen, R. Zhou, Y. Li, K.W. Leong, et al., J. Am. Chem. Soc. 2025, 147(8), 6612.
[20] Y. Zhang, M. Luo, X. Shi, A. Li, W. Zhou, Y. Yin, H. Wang, W.L. Wong, X. Feng, Q. He, Sci. Adv. 2024, 10(30), eadp4872.
[21] A. Pérez-Romero, M. Cano-Muñoz, C. López-Chamorro, F. Conejero-Lara, O. Palacios, J.A. Dobado, M.A. Galindo, Angew. Chem. Int. Ed. 2024, 63(11), e202400261.
[22] D. Wu, J. Zhou, Z. Zhang, Y. Cao, K. Ping, S. Qi, J. Du, G. Yu, Adv. Sci. (Weinh) 2025, 12(11), e2408518.
[23] 蔡伟, 巩仔鹏, 柴智, 张乐乐, 吴佳桐, 刘学伟. 中草药, 2024, 56(2), 753.
[24] 刘若雨, 王祖驰, 李肖. 药学学报, 2025, 60(9), 2752.
[25] B.K. Mehta, S.S. Singh, S. Chaturvedi, M. Wahajuddin, T.S. Thakur, Cryst. Growth Des. 2018, 18, 1581.
[26] Z. Zhou, W. Li, W.J. Sun, T. Lu, H.H.Y. Tong, C.C. Sun, Y. Zheng, Int. J. Pharm. 2016, 509, 391.
[27] J. Chen, H. Zeng, Langmuir 2022, 38(43), 12999.
[28] L. Jing, E. Deplazes, J.K. Clegg, X. Wu, Nat. Chem. 2024, 16(3), 335.
[29] S. Bansal, D. Liu, Q. Mao, N. Bauer, B. Wang, J. Med. Chem. 2024, 67(12), 9789.
[30] M.D. McCurry, G.D. D’Agostino, J.T. Walsh, J.E. Bisanz, I. Zalosnik, X. Dong, D.J. Morris, J.R. Korzenik, A.G. Edlow, E.P. Balskus, et al., Cell 2024, 187(12), 2952.
[31] J. Han, S. Wang, W. Fang, Y. Yang, R. Zhou, Y. Zhang, J. Yu, R. Tang, Z. Liu, Z. Gu, Nat. Cancer 2025, 6(6), 1.
[32] X. Yue, L. Peng, S. Liu, B. Zhang, X. Zhang, H. Chang, Y. Pei, X. Li, J. Liu, W. Shui, et al., Cell Res. 2025, 35(4), 1.
[33] L. Guo, K. Zhu, Y.N. Zhong, M. Gao, J. Liu, Z. Qi, Z. Liu, N. Rong, M. Zhang, D. Li, et al., Mol. Cell 2025, 85(8), 1658.
[34] L.N. Chen, H. Zhou, K. Xi, S. Cheng, Y. Liu, Y. Fu, X. Ma, P. Xu, S.Y. Ji, W.W. Wang, et al., Mol. Cell 2025, 85(8), 1640.
[35] M.K. Howard, N. Hoppe, X.P. Huang, D. Mitrovic, C.B. Billesbølle, C.B. Macdonald, E. Mehrotra, P. Rockefeller Grimes, D.D. Trinidad, L. Delemotte, et al., Cell 2025, 188(3), 671.
[36] X. Wen, P. Shang, H. Chen, L. Guo, N. Rong, X. Jiang, X. Li, J. Liu, G. Yang, J. Zhang, et al., Cell 2025, 188(3), 653.
[37] B. Li, H. Ming, S. Qin, E.C. Nice, J. Dong, Z. Du, C. Huang, Signal Transduct. Target. Ther. 2025, 10(1), 72.
[38] 杜鹏, 高利增, 焦健, 范克龙, 阎锡蕴. 中国科学院院刊, 2024, 39(5), 809.
[39] 范克龙, 高利增, 魏辉, 江冰, 王大吉, 张若飞, 贺久洋, 孟祥芹, 王卓然, 樊慧真, 等. 化学进展, 2023, 35(1), 1.
[40] F. Zhang, Y. Zheng, L. Wang, Y. Kang, H. Dong, H. Li, X. Zhao, B. Li, H. Chen, J. Qiu, et al., ACS Nano 2024, 18(32), 21246.
[41] Q. Fu, S. Zhang, S. Shen, Z. Gu, J. Chen, D. Song, P. Sun, C. Wang, Z. Guo, Y. Xiao, et al., Nat. Biomed. Eng. 2024, 8(11), 1425.
[42] Y. Chen, X. Yang, K. Li, J. Feng, X. Liu, Y. Li, K. Yang, J. Li, S. Ge, ACS Nano 2024, 18(9), 7024.
[43] J. Liu, Y. Shi, Y. Zhao, Y. Liu, X. Yang, K. Li, W. Zhao, J. Han, J. Li, S. Ge, Adv. Sci. (Weinh) 2024, 11(18), e2307269.
[44] Z. Chen, Y. Yang, X. Qiu, H. Zhou, R. Wang, H. Xiong, J. Am. Chem. Soc. 2024, 146(31), 21568.
[45] 徐振娜, 丁浩冉, 徐子航, 吴梦茹, 朱叶寒, 周梦娇, 李遇伯, 樊慧蓉, 姚雅琦. 药学学报, 2025, 60(4), 919.
[46] J. Huang, X. Pan, N. Yan, Nat. Rev. Mol. Cell Biol. 2024, 25(11), 904.
[47] 临床批文+2! 学院谭俊教授团队自主研发新药获临床I期试验批件. [2025-08-21]. https://mp.weixin.qq.com/s/uPKtcxeEdjphv83tV0z7jw
[48] C. Li, Y. Wu, S. Bao, H. Li, Z. Xu, J. Yan, X. Yu, L. He, T. Zhang, W. Liu, et al., J. Am. Chem. Soc. 2025, 147(17), 14139.
[49] Q. Zhang, Q. Liang, G. Wang, X. Xie, Y. Cao, N. Sheng, Z. Zeng, C. Ren, JACS Au 2024, 4(10), 3869.
[50] U. Contaldo, D. Savant-Aira, A. Vergnes, J. Becam, F. Biaso, M. Ilbert, L. Aussel, B. Ezraty, E. Lojou, I. Mazurenko, Proc. Natl. Acad. Sci. U. S. A. 2024, 121(42), e2402862121.
[51] Y. Li, J. Ma, R. Wang, Y. Luo, S. Zheng, X. Wang, Cell Metab. 2024, 36(9), 2118.
[52] S. Wang, M. Qin, X. Fan, C. Jiang, Q. Hou, Z. Ye, X. Zhang, Y. Yang, J. Xiao, K. Wallace, et al., Ageing Res. Rev. 2024, 101, 102498.
[53] Y. Xia, X. Wei, P. Gao, C. Wang, A. de Jong, J.H.K. Chen, M.J. Rodríguez-Sánchez, A. Rodríguez-Nogales, P. Diez-Echave, J. Gálvez, et al., Nat. Microbiol. 2024, 9(10), 2600.
[54] H. Zhang, Y. Zhang, Y. Zhang, H. Li, M. Ou, Y. Yu, F. Zhang, H. Yin, Z. Mao, L. Mei, Nat. Commun. 2024, 15(1), 6783.
[55] J. Wang, S. Liang, D. Zhu, X. Ma, Q. Peng, G. Wang, Y. Wang, T. Chen, M. Wu, T.Y. Hu, et al., J. Am. Chem. Soc. 2024, 146(31), 21568.
[56] L. You, J. Kou, M. Wang, G. Ji, X. Li, C. Su, F. Zheng, M. Zhang, Y. Wang, T. Chen, et al., Nat. Commun. 2024, 15(1), 2268.
[57] 王一岩, 吴国政, 郑永和. 现代远程教育研究, 2024, No. 6, 46.