Abstract: Through structural investigation of hexamethylenetetramine (C₆H₁₂N₄), we developed a “tetrahedral” model for analyzing adamantane molecular structures using chemical spatial thinking. This study proposes a novel approach for examining stereoisomerism (particularly enantiomerism) in disubstituted adamantane and hexamethylenetetramine derivatives, characterized by three distinct substitution patterns: same-ring same-carbon, same-ring different-carbon, and different-ring different-carbon. Systematic analysis of disubstituted hexamethylenetetramine (C₆H₁₂N₄) and adamantane (C₁₀H₁₆) stereostructures was conducted using this tetrahedral model. Notably, the three-dimensional tetrahedral model can be dimensionally reduced to a two-dimensional planar triangle configuration, thereby establishing an innovative methodology for stereostructural analysis of these disubstituted compounds. This approach may offer new perspectives for investigating analogous stereochemical systems.

Key words: Adamantane, Tetrahedral, Model, Spatial thinking