University Chemistry ›› 2016, Vol. 31 ›› Issue (3): 64-67.doi: 10.3866/PKU.DXHX20160364

• Chemistry Laboratory • Previous Articles     Next Articles

Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step

Jin LIU*(),Kun WEI,Le CAI,Qiu-E CAO,Shi-Xi LIU   

  • Published:2016-04-06
  • Contact: Jin LIU
  • Supported by:


An improved synthesis of benzocaine is described. The synthetic route developed involves trichloroisocyanuric acid and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) co-oxidation system as the key step. The method could avoid high toxicity, pollution, post-processing difficulties and other unfavorable environmental factors. The reactions were carried out under room temperature for short time with high yield and safe, easy, and environment-friendly operation.

Key words: Green chemistry, Benzocaine, Oxidation, Trichloroisocyanuric acid, TEMPO