电化学介导的直接氨基化反应构筑半缩胺醛骨架

doi:10.12461/PKU.DXHX202405060

University Chemistry ›› 2025, Vol. 40 ›› Issue (2): 272-277.doi: 10.12461/PKU.DXHX202405060

Special Issue:

• Chemistry Laboratory • Previous Articles Next Articles

Electrochemistry Mediated Direct Amination to Construct the Hemiaminal Ether Skeletons (HESs)

Ke Liu¹, Mingjing Deng¹, Jingbo Chang¹, Ailing Wang¹, Guoshuai Wu¹, Longyang Dian^1,2

1 State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, Shandong Province, China;
2 Suzhou Institute of Shandong University, Suzhou 215123, Jiangsu Province, China

Received:2024-05-07 Accepted:2024-07-25 Published:2025-02-22
Contact: Longyang Dian E-mail:longyang_dian@sdu.edu.cn

Abstract

Abstract: This paper presents a novel electrochemical synthesis experiment designed for undergraduate education, utilizing inexpensive and readily available benzotriazole and tetrahydrofuran as starting materials. The experiment successfully achieves the direct amination of ether-derived carbon-hydrogen (C(sp³)―H) bonds at room temperature to construct hemiaminal ether skeletons (HESs). By integrating scientific research outcomes with innovative pedagogical approaches, this experiment aims to stimulate and cultivate students’ creative thinking while providing insights into the latest trends in modern green organic electrochemical synthesis.

Key words: Electrochemical synthesis, Green chemistry, Innovative experiments

Ke Liu, Mingjing Deng, Jingbo Chang, Ailing Wang, Guoshuai Wu, Longyang Dian. Electrochemistry Mediated Direct Amination to Construct the Hemiaminal Ether Skeletons (HESs)[J].University Chemistry, 2025, 40(2): 272-277.

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Electrochemistry Mediated Direct Amination to Construct the Hemiaminal Ether Skeletons (HESs)

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