University Chemistry ›› 2020, Vol. 35 ›› Issue (4): 173-177.doi: 10.3866/PKU.DXHX201912004

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Determination of Uric Acid by Gold Nanoparticles Colorimetry Based on Hydrogen Bonding

Liqiang Lu(), Han Wang, Huaiyuan Cao, Haofei Qie, Mingtao Wang, Yong Li, Xike Tian   

  • Received:2019-12-02 Accepted:2019-12-16 Published:2020-02-20
  • Contact: Liqiang Lu


High content of uric acid can cause gout and other diseases, and thus uric acid is one of the important biochemical indicators in clinical test. Detection of uric acid based on gold nanoparticle colorimetry combines the forefront of scientific research with the content of teaching, which can stimulate students' interest in learning, deepen their understanding of classical theories and increase their understanding of the forefront of scientific research. In this experiment, gold nanoparticles were used to detect uric acid by inhibiting the accumulation of gold nanoparticles induced by melamine after the reaction of uric acid with melamine. With the increase of the concentration of uric acid in the solution, the color of the solution changes from blue to red, and the difference is obvious. The visual effect is good and easy to observe.

Key words: Gold nanoparticles, Uric acid, Melamine, Colorimetry