University Chemistry ›› 2022, Vol. 37 ›› Issue (1): 2104034.doi: 10.3866/PKU.DXHX202104034

• Chemistry Laboratory • Previous Articles     Next Articles

Green Synthesis of Anticancer Quinoxalinone JNK3 Inhibitors: A Proposed Comprehensive Chemical Experiment

Mengshi Jin, Jiabin Shen, Jun Xu, Pengfei Zhang, Wanmei Li()   

  • Received:2021-04-13 Accepted:2021-05-20 Published:2021-05-25
  • Contact: Wanmei Li


This study illustrates an exploratory comprehensive experiment covering organic, medicinal chemistry and instrumental analysis. In this experiment, (Z)-enaminones with a 3, 4-dihydroquinoxalin-2(1H)-one with anticancer, antibacterial, antidiabetic and antiviral activities was selected as the synthesis and research object. The first use of a recyclable acid resin (Amberlyst 15) as heterogeneous catalyst, under the coordination of visible light catalysis, one step synthesis anticancer quinoxalinone JNK3 inhibitors. Based on validated studies in the hot frontier, this experiment helps students to learn the experimental method of classical Mannich reaction, and strengthen the understanding of professional knowledge; it also helps students to study heterogeneous catalytic and optical knowledge based on the most recent advance; students' exploration innovation consciousness is improved by combining with the expanded reading. It is suggested that the course of "Comprehensive Chemistry Laboratory" should be included in senior undergraduate and junior graduate students.

Key words: Mannich reaction, Enaminones, Quinoxalin-2(1H)-one, Photocatalysis, Heterogeneous catalysis