Abstract: The technology of ultrahigh performance liquid chromatography (UHPLC) and ion chromatography (IC) with valve switching method is suitable for the simultaneous analysis of samples containing organic compounds and inorganic anions, which simplifies the pretreatment process, eliminates the complex matrix, enriches inorganic anions, realizes the simultaneous analysis of organic compounds and inorganic anions, and improves the efficiency of chromatographic analysis. The technology of ultrahigh performance liquid chromatography and ion chromatography with valve switching method is introduced into the undergraduate instrument analysis experiment class, which deepens the students’ understanding of the special advantages of the new technology, improves the undergraduates’ ability to solve complex practical problems, widens the field and enriches the content of instrument analysis experiment. Of course, it is conducive to the cultivation of innovative and comprehensive talents.

Key words: Valve switching, UHPLC, IC, Instrumental analysis experiment