“Hofmann-Löffler-Freytag”型反应合成吡咯烷类化合物的研究进展

doi:10.3866/PKU.DXHX202006030

Abstract

Abstract:

Nitrogen-containing heterocycles exist widely in natural products, pharmaceuticals and optical materials. These molecules often exhibit high levels of biological and optical activities. Especially, the pyrrolidine derivatives are privileged structural units existed in natural products and pharmaceuticals. Therefore, the development of efficient methods to construct this ubiquitous structure unit is highly desirable. This paper introduces the development of Hofmann-Löffler-Freytag (HLF) reaction in synthesis of pyrrolidine derivatives. The major contents are including two aspects: 1) Halogen-mediated HLF reactions; 2) Non halogen-mediated HLF reactions.

Key words: Hofmann-Löffler-Freytag type reaction, Pyriolidine derivatives, Halogen-mediated, Non halogen-mediated

Mingyu Yang. Progress in Synthesis of Pyrrolidine Derivatives by Hofmann-Löffler-Freytag Type Reactions[J].University Chemistry, 2021, 36(6): 2006030.

Figures/Tables 17

References 35

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Progress in Synthesis of Pyrrolidine Derivatives by Hofmann-Löffler-Freytag Type Reactions

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