智能型药物控释可视化系统的构建与表征——高分子实验的新设计与教学实践

doi:10.3866/PKU.DXHX202304094

Abstract

Abstract:

This study presents a new experimental design and teaching practice for polymer chemistry, physical chemistry, and instrument analysis. Here, a type of thermosensitive polymer microgel was synthesized in an aqueous solution by free radical precipitation polymerization. The thermo-responsivity of these microgels was assessed using a UV-Vis spectrophotometer and dynamic light scattering instrument. These microgels were then utilized as carriers to construct a controlled drug delivery system, in which the drug was uploaded to the microgels in the swollen state and released from the microgels in the collapsed state. To understand the drug release process, a combination of color theory and chemical knowledge was proposed, in which the drug with visible range absorption was selected to "visualize" the drug release process, making it more intuitive and observable. Based on this perceptual understanding, the molecular diffusion mechanism of the drug release process was analyzed rationally. This experiment was based on cutting-edge green research results that have been widely investigated and verified. Moreover, this experiment, which can be extended to other responsive polymers and drugs, has universal applicability. This experiment can not only exercise basic operational ability but also help develop research skills for identifying and solving problems and improve students' innovation ability.

Key words: Thermo-sensitive microgels, Free radical precipitation polymerization, Controlled drug release system, Visual detection, Experimental teaching

Laiying Zhang, Hongyu Gou, Haini Zhuang, Yuhang Qin, Huijuan Qiu, Weitai Wu. Construction and Characterization of Intelligent, Controlled Drug Release Visualization Systems: A New Design and Teaching Practice of Polymer Experiments[J].University Chemistry, 2023, 38(12): 212-219.

Figures/Tables 7

References 14

1	Sohail M. F. ; Rehman M. ; Sarwar H. S. ; Naveed S. ; Salman O. ; Bukhari N. I. ; Hussain S. ; Webster T. J. ; Shahnaz G. Int. J. Nanomed. 2018, 13, 3145. doi: 10.2147/IJN.S164518
2	Ryany F. D. ; Paul A. M. ; David W. Recent Pat. Drug. Deliv. Formul. 2009, 3, 1. doi: 10.2174/187221109787158319
3	Kang J. ; Hwang J. ; Seo J. ; Kim H. ; Shin U. S. Mater. Sci. Eng. C-Mater. Biol. Appl. 2018, 91, 247. doi: 10.1016/j.msec.2018.05.052
4	李佩瑶; 黄月英; 李传灵; 卞俊. 药学实践杂志, 2019, 37 (3), 212.
5	Huang G. ; Gao J. ; Hu Z. B. ; John V. J. ; Bill C. P. ; Dan M. J. Control. Release 2003, 94 (2), 303.
6	Zhang Y. S. ; Khademhosseini A. Science 2017, 356, 500.
7	Tanaka T. ; Fillmore D. J. J. Chem. Phys. 1979, 70 (3), 1214. doi: 10.1063/1.437602
8	Ji X. F. ; Shi B. B. ; Wang H. ; Xia D. Y. ; Jie J. K. ; Wu Z. L. ; Huang F. H. Adv. Mater. 2015, 27 (48), 8062. doi: 10.1002/adma.201504355
9	Kim D. R. ; Napper D. H. Macromol. Rapid Commun. 1996, 17 (12), 845. doi: 10.1002/marc.1996.030171201
10	Napper D. H. ; Netschey A. ; Alexander A. E. J. Polym. Sci. Pol. Chem. 1971, 9 (1), 81. doi: 10.1002/pol.1971.150090107
11	Napper D. H. ; Alexander A. J. Polym. Sci. 1962, 61 (171), 127. doi: 10.1002/pol.1962.1206117116
12	Roseman T. J. ; Higuchi W. I. J. Pharm. Sci. 1979, 59 (3), 353.
13	Siepmann J. ; Peppas N. A. Adv. Drug Deliv. Rev. 2001, 48, 139. doi: 10.1016/S0169-409X(01)00112-0
14	张来英; 兰如月; 刘志红; 吴伟泰. 大学化学, 2021, 36 (2), 1912023. doi: 10.3866/PKU.DXHX201912023

[1]	Zijun Huang, Feng Wu, Shaofeng Pi, Saijin Huang, Zhengjun Fang. Knowledge Graph-based Development of AI Curriculum for Inorganic Chemistry Experiments and Exploration of New Teaching Paradigm [J]. University Chemistry, 2025, 40(9): 228-237.
[2]	Haifeng Ma, Xiaocong Tian, Fengbin Wang, Zhonghua Xi, QingWang. Design of College Chemistry Experiment Based on Product Quality Control: Taking “Optimization of Ferrous Fumarate Synthesis Process” as an Example [J]. University Chemistry, 2025, 40(7): 321-327.
[3]	Qiying Xia, Aixiang Wang, Dengxue Ma, Guokui Liu, Yunzhi Li, Xia Leng, Yaoyao Wei, Guangli Zhou. Science and Technology Empowerment, Production and Education Integration, High-Quality Applied Chemistry Talents Training 12345 Experimental Teaching System Innovation and Practice [J]. University Chemistry, 2025, 40(7): 18-25.
[4]	Guangtao Zhao, Zonghuai Liu. Application and Exploration of Old University Scientific Instruments in the Cultivation of Undergraduates’ Innovative Ability [J]. University Chemistry, 2025, 40(5): 383-390.
[5]	Shuhui Li, Rongxiuyuan Huang, Yingming Pan. Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment [J]. University Chemistry, 2025, 40(5): 357-365.
[6]	Shuyong Zhang, Zhong Wei, Gang Ni, Chunyan Sun, Jianping Li, Hualong Xu, Xijiang Han, Qiue Cao, Yanguang Wang, Yi Yang, Yuqiang Ding, Wenqing Zhang. Suggestions on Theoretical and Experimental Teaching Contents of Applied Chemistry Majors in Universities [J]. University Chemistry, 2025, 40(5): 1-8.
[7]	Feng Lu, Tao Wang, Qi Wang. Preparation and Characterization of Water-Soluble Silver Nanoclusters: A New Design and Teaching Practice in Materials Chemistry Experiment [J]. University Chemistry, 2025, 40(4): 375-381.
[8]	Pingping Zhang, Dong Xiao, Shiyu Zhou, Chuanqiu Tang. Research and Innovative Practice on the Reform of Instrument Analysis Experimental Teaching System for Talent Cultivation in Modern Industry [J]. University Chemistry, 2025, 40(4): 232-238.
[9]	Wenjun Yang, Qiaoling Tan, Wenjiao Xie, Xiaoyu Pan, Youyong Yuan. Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments [J]. University Chemistry, 2025, 40(3): 371-380.
[10]	Yuji Liu, Yuntian Zhang, Xu Jia, Zhiwei Zeng, Shupeng Zhang, Wei Dong, Yongxing Tang. Preparation of N―N Coupling Compounds via Nitrogen-Centered Radical Reaction [J]. University Chemistry, 2025, 40(1): 318-323.
[11]	Qiuping Liu, Asan Yang, Jinfa Cai, Ling Liu, Weirong Ji, Genrong Qiang. Developing a New Paradigm for Integrated Science and Education & Multidimensional Connectivity in Chemistry and Chemical Engineering Experimental Education: A Case Study at the National Demonstration Center for Experimental Chemistry and Chemical Engineering Education (Zhejiang University of Technology) [J]. University Chemistry, 2024, 39(7): 1-7.
[12]	Wei Zhang, Kunying Xing, Wei Li, Yan Geng, Bo Tang. Construction and Practice of National Experimental Teaching Demonstration Center of Chemistry (Shandong Normal University) [J]. University Chemistry, 2024, 39(7): 20-25.
[13]	Zhongbin Pan, Shijie Huang, Yunjie Luo, Hongzhen Xie. Design of a Comprehensive Experiment for Determining Permanganate Index (COD_Mn) in Drinking Water [J]. University Chemistry, 2024, 39(7): 354-360.
[14]	Haibo Zhang, Yuwen Liu, Qiong Ding, Chi Huang, Faqiong Zhao, Jinping Zhou. The Construction of National Demonstration Center for Experimental Chemistry Education and the Practice of Top-Notch Innovative Talent Cultivation [J]. University Chemistry, 2024, 39(7): 82-92.
[15]	Heng Zhang, Gang Liu, Zhenghu Xu, Ying Ma. Construction and Practice of Comprehensive Open and Innovative Chemistry Experimental Teaching System and Platform in the Context of Multidisciplinary Integration [J]. University Chemistry, 2024, 39(7): 56-63.

Construction and Characterization of Intelligent, Controlled Drug Release Visualization Systems: A New Design and Teaching Practice of Polymer Experiments

RichHTML

PDF

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 7

References 14

Related Articles 15

Metrics

Recommended 0