治疗COVID-19的小分子药物研究进展

doi:10.3866/PKU.DXHX202208060

Abstract

Abstract:

The COVID-19 pandemic has caused significant losses and suffering around the world. Although the SARS-CoV-2 vaccine has largely controlled the spread of the virus, the scientific and sustainable treatment of COVID-19 patients is still necessary to truly end the pandemic. Small-molecule drugs against COVID-19 have attracted the attention of the scientific community and industry owing to their unique advantages such as a simple delivery method, relatively high output, and immune response with lower probability. Fortunately, in the last three years, some potentially effective drugs have been proposed, and have achieved good results in clinical trials. This paper briefly introduces the research progress on small-molecule drugs since 2020 to provide reference for future SARS-CoV-2 research.

Key words: SARS-CoV-2, Small molecule drugs, RdRp, Azvudine, Paxlovid^TM

Bo Yuan, Chenyun Feng, Yaofeng Yuan. Research Progress on Small-Molecule Drugs for Treating COVID-19[J].University Chemistry, 2023, 38(8): 85-94.

Figures/Tables 5

References 48

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名称	靶点	结构	功能
Azvudine	RdRp		抑制SARS-CoV-2
Molnupiravir	RdRp		抑制SARS-CoV-2
Remdesivir	RdRp		抑制SARS-CoV-2
Paxlovid^TM	Mpro	奈玛特韦(Nirmatrelvi) 利托那韦(Ritonavir)	Nirmatrelvi用于抑制SARS-CoV-2； Ritonavir用于降低Nirmatrelvi代谢，提高药效
Dexamethasone	糖皮质激素受体(GR)		降低细胞因子水平
Baricitinib	AKK-1		降低细胞因子水平

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Research Progress on Small-Molecule Drugs for Treating COVID-19

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