Abstract: The substitution of heteroaromatics by nucleophilic carbon-centered radicals is known as the Minisci reaction. In this study, efficient synthesis of 4-(benzo[d]thiazol-2-yl)butan-2-one was achieved through radical alkylation between 1-methylcyclopropan-1-ol and benzo[d]thiazole under silver-catalyzed and aqueous conditions. This method offers advantages such as simple operation procedures, mild reaction conditions, and excellent atom-economy. Undergraduates have successfully validated this reaction, making it a suitable candidate for a teaching experiment that effectively supplements knowledge in radical chemistry.

Key words: Minisci reaction, 1-Methylcyclopropan-1-ol, Benzo[d]thiazole, Radical alkylation, Teaching experiment