Abstract: There are numerous hazards present in university chemistry teaching laboratories. Improper implementation of management methods and technical measures can result in injuries to both teachers and students, consequently disrupting the normal flow of experimental teaching. The negative list management system allows for a concise and comprehensive summary of issues encountered during various experimental teaching and laboratory management processes. Proper organization and continuous improvement of the negative list is one effective approach to strengthening the safety management of chemistry teaching laboratories in universities. This article, based on an analysis of the various factors impacting current university chemistry teaching laboratories, establishes a targeted negative list. It also promotes targeted laboratory safety education and training, the implementation of effective laboratory engineering and technical safety measures, and the reinforcement of mandatory laboratory safety measures. This approach, combined with the 3E method, forms a chemistry teaching laboratory safety model. The sustained development of this model, in conjunction with the negative list management system, has yielded positive results in the management of chemistry teaching laboratories and serves as a valuable reference for the safety management of such laboratories in universities.

Key words: Negative list management system, Safety education and training, Engineering and technical safety measures, Security enforcement measures, Chemical laboratory