Abstract: Photocatalytic oxidation, distinguished by its safety, controllability, mild conditions, and environmental friendliness compared to traditional oxidation reactions, has emerged as a prominent research focus in the forefront of chemistry, garnering widespread attention. However, its application in undergraduate teaching experiments has been limited by experimental conditions and equipment constraints. In this experiment, we devised a simple photoreaction device using conventional laboratory instruments. Employing a high-efficiency, low-energy sodium lamp as the light source to catalyze the oxidation of phosphate intermediates, we achieved the laboratory-scale synthesis of 1,2-dioxocycloethane-type medical chemiluminescence reagents, diversifying the application of photochemical reactions in experimental teaching. The materials and reagents used in this experiment are inexpensive and readily available, the operation is straightforward, and the yield of the product is high. The experiment allows for both independent single-bottle operations and the execution of multiple-bottle series reactions. Considering the experimental cost and teaching efficiency, we conducted group experimental teaching with a two-bottle series, fostering diverse teaching forms and nurturing students’ cooperative skills. This approach is well-suited for undergraduate experimental teaching, aiding students in enhancing their comprehensive experimental operational abilities and deepening their understanding of reaction mechanisms such as radical coupling.

Key words: Photocatalytic oxidation, Safe and controllable, Medical chemiluminescence reagent, Radical coupling