浅谈2024年诺贝尔化学奖——通过计算模拟和人工智能破译蛋白质结构的奥秘

doi:10.12461/PKU.DXHX202411061

Abstract

Abstract: Proteins play major roles in all life activities, and the three-dimensional (3D) structures of proteins are closely related to their biological functions. In 2024, half of the Nobel Prize in Chemistry was awarded to Dr. Demis Hassabis and Dr. John Jumper from DeepMind, for their breakthrough contributions to protein structure prediction. The other half was awarded to Prof. David Baker from the University of Washington, for his systematic research in computational protein design. Here, we briefly review the research milestones of protein structure prediction and design, and prospect their cutting-edge applications.

Key words: Nobel Prize in Chemistry, Protein folding, Protein structure prediction, Computational protein design, Rosetta, AlphaFold

Fengzhang Wang, Yuan Liu, Chu Wang. A Brief Introduction to Nobel Prize in Chemistry 2024: Deciphering the Mysteries of Protein Structures by Computational Modelling and Artificial Intelligence[J].University Chemistry, 2025, 40(1): 75-81.

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A Brief Introduction to Nobel Prize in Chemistry 2024: Deciphering the Mysteries of Protein Structures by Computational Modelling and Artificial Intelligence

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