Abstract: This paper is proposed in the context of limited class hours. Aiming at the problems existing in the teaching process of "hybrid orbital theory" in general chemistry, the "Five-Question" model is introduced to guide students' deep thinking and understanding of this theory. Through analyzing the theoretical basis, hybridization conditions, reasons, principles, and types of hybrid orbitals, it elaborates on how to use this model to stimulate students' active thinking, enhance teaching intuitiveness and convenience, and cultivate students' problem-solving abilities and scientific thinking.

Key words: University chemistry, Hybrid orbital theory, Teaching reform