Abstract: This narrative follows young scholar Lin Mo's dream journey after academic setbacks, where he encounters CiPS-073, a chemically induced pluripotent stem cell sprite. Through temporal exploration and scientific discourse, the story systematically examines key breakthroughs in chemically induced pluripotent stem cell research. The cellular sprite guides Lin Mo through pivotal moments: John Gurdon's nuclear transfer experiments in Xenopus laevis (marking the inception of somatic cell differentiation reversal), Shinya Yamanaka's team's landmark achievement and subsequent concerns regarding induced pluripotent stem cells (iPSCs) using four transcription factors, and the exploration of small molecules as transcription factor alternatives. The narrative elaborates on chemical reprogramming's molecular mechanisms, particularly highlighting the breakthrough by Hongkui Deng's team in China—employing epigenetic reset agents and small molecule combinations to bypass the extraembryonic endoderm intermediate state, significantly reducing somatic cell reprogramming time. The story explores iPSC applications in neurodegenerative diseases, myocardial infarction repair, diabetes treatment, and age-related macular degeneration therapy. Through dialogues with the cellular sprite, Lin Mo gains insight into the evolutionary significance of “program errors” and ultimately recognizes the value of scientific failure, awakening with renewed determination. Centered on the theme “failure drives innovation”, the story encourages young scholars to transform research challenges into opportunities, offering dual enlightenment in scientific literacy and life philosophy.

Key words: Chemically induced pluripotent stem cells, Transcription factors, Combination of chemical small molecules, Chemical reprogramming