Abstract:

Flow chemistry technology has become one of the most promising technologies in organic synthesis due to its high heat and mass transfer efficiency, high reaction safety, short reaction time and precise control of reaction parameters compared with conventional batch reaction. Many universities abroad have set up the experiment of flow chemistry, while it is still in its infancy in China. In this study, the classic Claisen-Schmidt reaction in organic chemistry experiment was improved through the liquid-liquid flow chemical reaction platform. The reaction process was monitored by UV-Vis Spectrophotometry. Under the same teaching purpose, this experiment has the distinct advantages of short reaction time, obvious phenomenon and less alkali dosage.

Key words: Flow Chemistry, Claisen-Schmidt reaction, Chalcone derivative, Synthesis