Abstract: As a “guardian” of crop health, pesticides play an irreplaceable role in effectively preventing and controlling diseases and pests, reducing crop losses, and ensuring food security and social stability. However, traditional pesticide applications are often associated with low utilization rates and severe environmental pollution. Leveraging its unique methodological and technological advantages, the field of chemistry provides key solutions for the green development of pesticides through critical approaches such as green molecular design, adjuvant-mediated interfacial deposition regulation, construction of intelligent controlled-release delivery systems, and pesticide residue and safety assessment. These technologies respectively aim to reduce the ecological toxicity of pesticides at the source, address the challenge of droplet deposition and retention on leaves, achieve precise on-demand release, and systematically evaluate and manage residue risks, working synergistically to enhance pesticide efficiency and environmental compatibility. In the future, chemistry will further integrate multidisciplinary technologies including artificial intelligence, synthetic biology, and materials science to establish a full-chain green pesticide technology system, offering solid scientific and technical support for advancing agricultural sustainable development and global agricultural green transformation.

Key words: Chemistry, Pesticide, Molecular design, Adjuvant regulation, Delivery system, Safety assessment, Green development