Abstract: Aligned with the talent development objectives of the Chemistry “101 Plan”, this study employs carbene intermediates as a conceptual bridge to incorporate advanced single-atom skeletal editing research into organic chemistry pedagogy. Through a three-phase instructional model encompassing “theoretical fundamentals, literature analysis, and innovative design”, students are guided to apply foundational carbene chemistry principles to examine the mechanisms of single-atom skeletal editing in indole molecules. This teaching paradigm demonstrates a replicable approach for integrating core knowledge with frontier research, contributing to the ongoing reform of organic chemistry curricula.

Key words: Chemistry “101 Plan”, Curriculum reform, Organic chemistry, Carbene, Indole, Single-atom skeletal editing