大学化学 >> 2025, Vol. 40 >> Issue (11): 362-368.doi: 10.12461/PKU.DXHX202502003

师生笔谈 上一篇    下一篇

以有机聚合物整体柱为例探讨van Deemter方程在仪器分析教学中的应用

陈庚嘉, 欧俊杰   

  1. 西北大学化学与材料科学学院, 西安 710127
  • 收稿日期:2025-02-08 录用日期:2025-04-18 发布日期:2025-11-21
  • 通讯作者: 欧俊杰 E-mail:junjieou@nwu.edu.cn Junjie Ou
  • 基金资助:
    国家自然科学基金(22142014)

Application of the van Deemter Equation in Instrumental Analysis Teaching: A Case of Organic Polymer Monolithic Columns

Gengjia Chen, Junjie Ou   

  1. College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China
  • Received:2025-02-08 Accepted:2025-04-18 Published:2025-11-21
  • Contact: Junjie Ou E-mail:junjieou@nwu.edu.cn

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摘要： 在仪器分析领域，高效液相色谱(HPLC)具有举足轻重的作用，然而大学仪器分析课程未能深刻剖析固定相的精细结构和van Deemter方程中关键变量对分离效果的影响。本文以自由基聚合法和点击聚合法所制备有机聚合物整体柱为例，探讨了其结构和形貌对van Deemter方程中A、B、C三项的影响，力求使学生能够更加清晰地把握van Deemter方程的核心。

关键词: 整体柱, 仪器分析, 高效液相色谱, van Deemter方程

Abstract: High-performance liquid chromatography (HPLC) occupies a pivotal position in the field of instrumental analysis. Nevertheless, current university courses in instrumental analysis often lack in-depth exploration of the intricate structure of stationary phases and the critical variables in the van Deemter equation that influence separation efficiency. This paper examines organic polymer monolithic columns prepared through traditional free radical polymerization and click polymerization methods, analyzing how their structure and morphology affect the A, B, and C terms of the van Deemter equation. The aim is to enhance students' understanding of the fundamental principles underlying the van Deemter equation.

Key words: Monolithic column, Instrumental analysis, High-performance liquid chromatography, van Deemer equation