University Chemistry ›› 2025, Vol. 40 ›› Issue (2): 11-19.doi: 10.12461/PKU.DXHX202402048

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Experimental Course Design and Application of Nanopore Electrochemical Instrument for Single-Molecule Measurements

Zhengli Hu1, Yilun Ying1, Jia Wang1, Chengbing Zhong1, Xuanfeng Kong2, Xiaodong Yu2, Wenwei Zhang2, Jianrong Zhang2, Yitao Long1   

  1. 1 Molecular Sensing and Imaging Center (MSIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China;
    2 National Demonstration Center for Experimental Chemistry Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
  • Received:2024-02-23 Accepted:2024-06-11 Published:2025-02-22
  • Contact: Yilun Ying E-mail:yilunying@nju.edu.cn

Abstract: Integrating scientific research with the experiments for analytical measurements is crucial for early engagement of chemistry undergraduates in Nanjing University. This approach not only facilitates practical scientific exploration but also integrates ideological and political education to help students correct values, nurture their research interests, and enhance their academic literacy. This paper presents a case study of the undergraduate course “Nanopore Electrochemical Measurement of Single Molecules”, conducted using a homemade instrument. The course adopts a student-centered two-phase experimental teaching mode that transitions from “verification learning” to “independent exploration”. Throughout the teaching process, the ideological and political elements such as self-improvement and innovation are integrated to inspire students to master cutting-edge scientific technologies and engage in independent exploratory activities. This course design effectively meets the educational goals of values, knowledge, and skills, providing valuable insights for developing and reforming chemistry experimental courses that incorporate scientific research.

Key words: Nanopore electrochemistry, Single-molecule measurement, Instrumental chemistry experiment, Ideological and political education, Scientific research integration