Abstract: In response to the requirements of the Ministry of Education’s “101 Plan” for cultivating top-tier talents in chemistry, this study focuses on the deep integration of organic chemistry and biology, exploring innovative practices in curriculum teaching. We propose incorporating interdisciplinary knowledge merging chemistry and biology into the basic organic chemistry course. By introducing prebiotic chemical reactions, general acid-base catalysis, redox reactions in bioorganic systems, as well as biomimetic and artificial enzyme catalysis from the perspectives of organic reaction mechanisms and molecular principles, this approach elucidates the dialectical unity between enzymatic mechanisms and synthetic chemistry principles. The curriculum design integrating chemical-biological knowledge not only enhances students’ understanding of the essence of organic reactions but also cultivates interdisciplinary thinking and innovative abilities, providing a reference for reforming chemistry education in the new era.

Key words: Interdisciplinary integration, Organic chemistry, Teaching reform, Talent cultivation, Innovative practice