走近Catellani反应：从经典偶联到芳环多位点精准官能团化

doi:10.12461/PKU.DXHX202608050

Abstract

Abstract: The Catellani reaction is a named reaction in palladium catalysis that leverages palladium/norbornene cooperative catalysis to achieve sequential ortho C–H functionalization of aryl halides and ipso coupling at the halogen site, thereby enabling the efficient construction of polysubstituted arenes. This article introduces its discovery background, catalytic mechanism, research progress, and representative applications in the total synthesis of natural products, and discusses its value in undergraduate organic chemistry education, with the aim of providing a reference for organic chemistry teaching and research practice.

Key words: Catellani reaction, Palladium catalysis, Norbornene, Polysubstituted arenes, Undergraduate teaching

Zhengzheng Meng, Liying Zhao, Qianghui Zhou, Hong-Gang Cheng. The Catellani reaction: from classical cross-coupling to siteselective and modular functionalization of aromatics[J].University Chemistry, 2026, (): 2608050.

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The Catellani reaction: from classical cross-coupling to siteselective and modular functionalization of aromatics

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