Abstract: The new era is characterized by knowledge production diversity, interdisciplinary and collaborative innovation. Engineering universities urgently need to update their scientific talent cultivation mechanisms to stay aligned with these evolving demands. Over the past twenty years, the Department of Materials Chemistry at Harbin Institute of Technology has responded to the major strategic needs of national aerospace. It has developed a unique “Big Chemistry” approach to science education, characterized by its aerospace and defense focus and a “Trinity and Multidimensional Integration” model that combines multiple disciplines. This paper provides a systematic exploration and implementation of this model, detailing the formation process, conceptual framework, construction of a molecular knowledge system, and the cultivation of cross-disciplinary practical skills through “Triple mentorship and Triple Practice”.

Key words: Interdisciplinary, Science discipline, Aerospace defense characteristics, Talent training