过氧化氢：小分子，大作用

doi:10.3866/PKU.DXHX202006034

Abstract

Abstract:

Hydrogen peroxide is a small molecule with a fine structure and wide applications. It plays important roles in bleaching, medicine, the chemical industry, environmental protection, food industry, rocket fuel etc. Here, in addition to providing a brief comprehensive introduction on the structure, chemical properties and syntheses of hydrogen peroxide, we primarily present its biological functions, detection methods, applications and safety, with the aim of enhancing the understanding of this smart molecule.

Key words: Hydrogen peroxide, Chemical synthesis, Biological function, Detection method, Application, Safety

Houjin Li, Jinshan Li, Liuping Chen. Hydrogen Peroxide: Small Molecule with Big Functions[J].University Chemistry, 2021, 36(6): 2006034.

Figures/Tables 4

References 41

1	De Grey A. D. N. J. DNA Cell Biol. 2002, 21 (4), 251. doi: 10.1089/104454902753759672
2	Richard, L. M. The 100 Most Important Chemical Compounds: a Reference Guide, 1st ed.; Greenwood Press: Connecticut, USA, 2007; pp. 144-146.
3	Koppenol W. H. ; Sies H. Nature 2018, 559 (7713), 181.
4	Liang M. C. ; Hartman H. ; Kopp R. E. ; Kirschvink J. L. ; Yung Y. L. P. Natl. Acad. Sci. USA 2006, 103 (50), 18896. doi: 10.1073/pnas.0608839103
5	Mostofa, K. M. G.; Yoshioka, T.; Mottaleb, A.; Vione, D. Photobiogeochemistry of Organic Matter, Principles and Practices in Water Environments, 1st ed.; Springer: Heidelberg, Germany, 2013; pp. 139-207.
6	Pesterfield L. J. Chem. Educ. 2009, 86 (10), 1182. doi: 10.1021/ed086p1182
7	Busing W. R. ; Levy H. A. J. Chem. Phys. 1965, 42 (9), 3054. doi: 10.1063/1.1696379
8	Giguere P. A. J. Chem. Educ. 1983, 60 (5), 399. doi: 10.1021/ed060p399
9	Talsi E. P. ; Bryliakov K. P. Coordin. Chem. Rev. 2012, 256, 1418. doi: 10.1016/j.ccr.2012.04.005
10	Burek B. O. ; Bormann S. ; Hollmann F. ; Bloh J. Z. ; Holtmann D. Green Chem. 2019, 21 (12), 3232. doi: 10.1039/C9GC00633H
11	Ranganathan S. ; Sieber V. Catalysts 2018, 8 (9), 379. doi: 10.3390/catal8090379
12	Campos-Martin J. M. ; Blanco-Brieva G. ; Fierro J. L. G. Angew. Chem. Int. Edit. 2006, 45 (42), 6962. doi: 10.1002/anie.200503779
13	胡长诚. 化学推进剂与高分子材料, 2003, 19 (1), 14.
14	Tomita O. ; Otsubo T. ; Higashi M. ; Ohtani B. ; Abe R. ACS Catal. 2016, 6 (2), 1134. doi: 10.1021/acscatal.5b01850
15	Kimura M. ; Yamamoto M. ; Nagai A. Inorg. Chim. Acta 1986, 117 (2), 169. doi: 10.1016/S0020-1693(00)82194-5
16	Perry S. C. ; Pangotra D. ; Vieira L. ; Csepei L. I. ; Sieber V. ; Wang L. ; Ponce de Leon C. ; Walsh F. C. Nat. Rev. Chem. 2019, 3 (7), 442. doi: 10.1038/s41570-019-0110-6
17	Shiraishi Y. ; Kanazawa S. ; Kofuji Y. ; Sakamoto H. ; Ichikawa S. ; Tanaka S. ; Hirai T. Angew. Chem. Int. Edit. 2014, 53 (49), 13454. doi: 10.1002/anie.201407938
18	Liu J. ; Zou Y. ; Jin B. ; Zhang K. ; Park J. H. ACS Energy Lett. 2019, 4 (12), 3018. doi: 10.1021/acsenergylett.9b02199
19	Ranganathan S. ; Sieber V. Catalysts 2018, 8 (9), 379. doi: 10.3390/catal8090379
20	Freakley S. J. ; He Q. ; Harrhy J. H. ; Lu L. ; Crole D. A. ; Morgan D. J. ; Ntainjua E. N. ; Edwards J. K. ; Carley A. F. ; Borisevich A. Y. ;et al Science 2016, 351 (6276), 965. doi: 10.1126/science.aad5705
21	Xia C. ; Xia Y. ; Zhu P ; Fan L. ; Wang H. T. Science 2019, 366(6462),226. doi: 10.1126/science.aay1844
22	Zhang M. F. ; Hao J. C. ; Neyman A. ; Wang Y. F. ; Weinstock I. A. Inorg. Chem. 2017, 56 (5), 2400. doi: 10.1021/acs.inorgchem.6b02167
23	Kim H. J. J. Microbiol. Biotechn. 2014, 24 (11), 1455. doi: 10.4014/jmb.1407.07072
24	Cerny M. ; Habanova H. ; Berka M. ; Luklova M. ; Brzobohaty B. Int. J. Mol. Sci. 2018, 19 (9), 2812. doi: 10.3390/ijms19092812
25	Lennicke C. ; Rahn J. ; Lichtenfels R. ; Wessjohann L. A. ; Seliger B. Cell Commun. Signal. 2015, 13 (1), 39. doi: 10.1186/s12964-015-0118-6
26	Filomeni G. ; De Zio D. ; Cecconi F. Cell Death Differ. 2015, 22 (3), 377. doi: 10.1038/cdd.2014.150
27	Wang Y. ; Branicky R. ; Noe A. ; Hekimi S. J. Cell Biol. 2018, 217 (6), 1915. doi: 10.1083/jcb.201708007
28	Chaiswing L. ; St. Clair W. H. ; St. Clair D. K. Antioxid. Redox Sign. 2018, 29 (13), 1237. doi: 10.1089/ars.2017.7485
29	Weinberg F. ; Ramnath N. ; Nagrath D. Cancer-Am. Cancer Soc. 2019, 11 (8), 1191.
30	Glasauer A. ; Chandel N. S. Biochem. Pharmacol. 2014, 92 (1), 90.
31	Rajendran P. ; Nandakumar N. ; Rengarajan T. ; Palaniswami R. ; Gnanadhas E. N. ; Lakshminarasaiah U. ; Gopas J. ; Nishigaki I. Clin. Chim. Acta 2014, 436, 332. doi: 10.1016/j.cca.2014.06.004
32	Fransen M. ; Lismont C. Antioxid. Redox Sign. 2019, 30 (1), 95. doi: 10.1089/ars.2018.7515
33	常青; 江国栋; 唐和清; 崔龙哲; 吕康乐; 吴来燕. 实验室科学, 2014, 17 (2), 27.
34	Chen X. Q. ; Wang F. ; Hyun J. Y. ; Wei T. W. ; Qiang J. ; Ren X. T. ; Shin I. ; Yoon J. Chem. Soc. Rev. 2016, 45 (10), 2976. doi: 10.1039/C6CS00192K
35	Zhang W. ; Liu W. ; Li P. ; Huang F. ; Wang H. ; Tang B. Anal. Chem. 2015, 87 (19), 9825. doi: 10.1021/acs.analchem.5b02194
36	Cai L. L. ; Hou B. J. ; Shang Y. Y. ; Xu L. ; Zhou B. ; Jiang X. N. ; Jiang X. Q. Chem. Phys. Lett. 2019, 736, 136797. doi: 10.1016/j.cplett.2019.136797
37	Chen S. H. ; Yuan R. ; Chai Y. Q. ; Yin B. ; Xu Y. Electroanal. 2008, 20 (19), 2141. doi: 10.1002/elan.200804303
38	Zhang J. ; Gao L. Mater. Lett. 2007, 61 (17), 3571. doi: 10.1016/j.matlet.2006.11.138
39	刘杰; 赵振廷; 史健芳; 张文栋; 胡杰. 材料导报, 2016, 30 (24), 11.
40	Spoof L. ; Jaakkola S. ; Vazic T. ; Häggqvist K. ; Kirkkala T. ; Ventelä A. M. ; Kirkkala T. ; Svircev Z. ; Meriluoto J. Environ. Sci. Pollut. R. 2020, 27 (8), 8638. doi: 10.1007/s11356-019-07476-x
41	Zanelli M. ; Ragazzi M. ; De Marco L. Br. J. Clin. Pharmacol. 2017, 83 (2), 427. doi: 10.1111/bcp.13100

[1]	Cheng-an Tao, Jian Huang, Yujiao Li. Exploring the Application of Artificial Intelligence in University Chemistry Laboratory Instruction [J]. University Chemistry, 2025, 40(9): 5-10.
[2]	Wenrui Yao, Ce Sun, Bailing Chen, Yuanyuan Miao, Daxin Liang, Haiyan Tan, Dingyuan Zheng, Yanhua Zhang. Practical Exploration of AI Empowerment in Graduate Safety Education [J]. University Chemistry, 2025, 40(9): 126-131.
[3]	Daxin Liang, Yudong Li, Haiyue Yang, Bailing Chen, Zhiming Liu, Chengyu Wang. Reform and Practice of an AI-Empowered “Learning-Understanding-Application” Training Model in Materials Chemistry Education [J]. University Chemistry, 2025, 40(9): 253-263.
[4]	Liangyu Gong, Yongsheng Niu, Xiuzhong Wang, Lihua Lu, Lubin Xu, Shuaishuai Li, Jie Wang. The Exploration and Practice of Integrating “Agriculture, Science, and Education” to Cultivate Chemistry Talent with a Rich “Agrochemical” Background [J]. University Chemistry, 2025, 40(8): 330-337.
[5]	Chen Hu, Yu Wu, Lianqing Chen, Tao Huang, Chunya Li, Lin Li, Bingguang Zhang, Peng Mei. Innovation and Exploration of Chemical Laboratory Safety Curriculum Based on the “Trinity and Four Integrations” Strategy [J]. University Chemistry, 2025, 40(8): 25-32.
[6]	Weiguang Zhao. Reflections and Recommendations on Emergency Response to Common Safety Incidents in Chemical Laboratories [J]. University Chemistry, 2025, 40(8): 291-297.
[7]	Nan Wu, Hang Zhang, Lingling Wei, Quan Gu, Haoquan Zheng, Weiqiang Zhang, Rui Cao. Cyanide: Poison or Treasure? [J]. University Chemistry, 2025, 40(7): 177-188.
[8]	Xia Yin, Peng Yang, Feng Xu, Yan Zhao, Shuangyan Huan, Jingzhe Zhao, Gonglan Ye, Yingpeng Wu. Exploration and Practice of Ideological and Political Education in Inorganic Chemistry Experiment Course [J]. University Chemistry, 2025, 40(7): 119-126.
[9]	Ying Liu, Jia Ji, Yinling Hou, Lilan Guo, Xuan Lv. Selenium’s Journey [J]. University Chemistry, 2025, 40(7): 218-224.
[10]	Yuheng Zhou. Colorful Chemistry in University: Exploring the Beauty of Transition Elements [J]. University Chemistry, 2025, 40(6): 303-309.
[11]	Yan Qi, Yueqin Yu, Weisi Guo, Yongjun Liu. Case-based Teaching Exploration and Practice in Transition Metal-Mediated Organic Reactions [J]. University Chemistry, 2025, 40(6): 111-117.
[12]	Wei Li, Jinfan Xu, Yongjun Zhang, Ying Guan. Preparation of Covalent Organic Framework Monolithic Material for Non-Targeted Food Safety Screening: A Recommended Comprehensive Instrumental Analysis Chemistry Experiment [J]. University Chemistry, 2025, 40(6): 276-285.
[13]	Yihui Song, Shangshang Qin, Kai Wu, Chengyun Jin, Bin Yu. Cross-Integration Application of Biochemistry in the Cultivation of High-Level Innovative Pharmaceutical Talents: A Case Study on the Activity Evaluation of Demethylase LSD1 Inhibitors [J]. University Chemistry, 2025, 40(6): 341-352.
[14]	Ling Yang, Yupeng Guo, Jingcheng Ji, Xiangjuan Qi, Chuanli Qin, Pingping Zhu, Shuyong Zhang. Suggestions on Teaching Contents and Requirements of Chemistry Laboratory Safety for Chemistry Majors in Higher Education [J]. University Chemistry, 2025, 40(5): 15-22.
[15]	Yu Dai, Xueting Sun, Haoyu Wu, Naizhu Li, Guoe Cheng, Xiaojin Zhang, Fan Xia. Determination of the Michaelis Constant for Gold Nanozyme-Catalyzed Decomposition of Hydrogen Peroxide [J]. University Chemistry, 2025, 40(5): 351-356.

Hydrogen Peroxide: Small Molecule with Big Functions

RichHTML

PDF

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 4

References 41

Related Articles 15

Metrics

Recommended 0