肾源性系统性纤维化疾病的化学机制和双鳌合剂法的抑制研究

doi:10.3866/PKU.DXHX202209029

Abstract

Abstract:

A small proportion of nephropathy patients administered gadolinium contrast agents for nuclear magnetic resonance have been reported to develop nephrogenic systemic fibrosis (NSF). This paper introduces the mechanism of the transformation and deposition of NSF, aiming to reveal the chemical nature of the gadolinium phosphate bioparticles in nephrogenic system fibrosis. This research will provide an important theoretical basis for future studies on the occurrence, development, and formation of nephrogenic system fibrosis and the removal of sediment residues. Moreover, a new idea for introducing a biocompatible second chelating agent into the gadolinium contrast agent system has been proposed, which aims to improve the safe use of gadolinium contrast agent.

Key words: Nephrogenic systemic fibrosis, Gadolinium contrast agent, Chelation, Chemical mechanism

Xinqi Zhan, Zhaohui Zhou. Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation[J].University Chemistry, 2023, 38(12): 86-90.

Figures/Tables 4

References 29

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Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation

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