关键词: 基础知识, 前沿进展, 有机合成, 教学方法, 课程思政

Abstract: Organic synthesis serves as a pivotal foundational course for chemistry-related disciplines in higher education, characterized by its strong practical orientation. However, students frequently encounter challenges in comprehending, retaining, and applying the extensive array of knowledge points and reactions inherent in this subject. To address these pedagogical difficulties, this study proposes an innovative teaching model that effectively integrates fundamental principles with cutting-edge developments, using the asymmetric Meinwald rearrangement as a representative case. Through systematic exploration of this reaction's historical development, mechanistic insights, asymmetric transformations, and applications in natural product synthesis, the model establishes meaningful connections within textbook-based fundamental concepts and key reaction types, including oxidation-reduction and rearrangement processes. This integrative approach facilitates students' comprehension of knowledge frameworks, enabling them to develop more concrete and profound understanding of the subject matter, thereby enhancing both conceptual grasp and retention. Furthermore, the incorporation of ideological and political education elements fosters students' scientific curiosity and spirit of exploration, while simultaneously cultivating essential awareness of laboratory safety and environmental protection. This comprehensive pedagogical strategy contributes significantly to the development of high-caliber professionals equipped with steadfast political convictions, exemplary moral character, and robust professional competencies.

Key words: Fundamental knowledge, Cutting-edge developments, Organic synthesis, Teaching methodology, Ideological and political education