Abstract:

Chirality is the essential attribute of life. Molecular chirality is closely related to the fine regulation of life phenomena. The pharmacology and toxicology of drugs with different enantiomers vary significantly different. Owing to the recent advancements in the chiral drug market, the development of efficient and accurate chiral separation strategy has become critical. Aiming at the construction of new engineering subjects 2.0, the idea of "chiral separation workshop" comprehensive experiment was proposed for the first time. The chiral recognition mechanism based on intermolecular weak interaction was investigated using the click-chemical green synthesis strategy to realize the highly efficient grafting of single-positively charged cyclodextrins and the construction of positively charged supramolecular chiral media; the chiral separation conditions of racemic amino acid derivatives were optimized, and the resolution of racemic dansyl amino acids were obtained as well. The experiment is based on the construction of new engineering chemistry specialty, covering the basic chemical knowledge of green synthesis, accurate instrument analysis, physical and chemical separation mechanism, and inorganic material chemistry, as well as integrating the advanced technical theories and industrial applications, thereby creating a new paradigm for the cultivation of chemistry talents under the guidance of ideological and political education.

Key words: Cationic cyclodextrin, Green click chemistry, Course ideology and politics, Chemistry experiment