Abstract: Based on "fentanyl" event, the heterocyclic chemistry curriculum system was improved by using opioid heterocyclic compounds as ideological and political cases, which integrate knowledge transfer, value shaping, and science popularization. The author attempts to use natural analgesic isoquinoline heterocyclic drugs as examples, their physico-chemical properties, synthesis, and application of these isoquinoline heterocyclic drugs are implemented throughout the whole teaching process. The reform of heterocyclic chemistry classroom teaching via case-based teaching methods could effectively aroused students’ enthusiasm as well as initiative for learning, and thus significantly improved the teaching effects.

Key words: Heterocyclic chemistry, Case-based teaching, Opioid heterocyclic drugs, Ideological and political educaiton