仪器分析课程中绿色度概念的引入

doi:10.3866/PKU.DXHX202304048

Abstract

Abstract:

In order to fulfill organic combination of professional goal and moral goal from the course of instrumental analysis and student education, and unification of green analytical chemistry from discipline concept and the social responsibility of green development, greenness the evaluation index for describing the greening of analytical methods was introduced into our instrumental analysis course. Firstly, the development of green chemistry, green analytical chemistry and green liquid chromatography was briefly covered. Secondly, various methods for quantitative expression of greenness were presented, and the two methods of HPLC-EAT and CHEMS-1 were emphasized, involving their usages, scope of application and limitations. Finally, the two methods were employed for calculating the greenness values of the liquid chromatography methods selected from literatures, and the correlation analysis between the calculation results from the two methods were done. It was shown that the data from the two methods were not the same, but their correlation was good. Both HPLC-EAT and CHEMS-1were capable of measuring greenness of liquid chromatography, and the two methods were easy for students to grasp. We would like to recommend that the concept of greenness and together with the two methods for calculating greenness should be adopted in instrumental analysis textbooks in the future.

Key words: Greenness, Green chemistry, Chromatography, Instrumental analysis course

Hongyi Zhang, Junyao He, Zhihong Shi. Introduction of the Concept of Greenness into Instrumental Analysis Course[J].University Chemistry, 2023, 38(11): 293-300.

Figures/Tables 4

References 30

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类别	化合物名称	CAS	tHV	taHV
烃类	戊烷(Pentane)	109-66-0	23.4	36.4
	己烷(Hexane)	110-54-3	53.8	81.4
	环己烷(Cyclohexane)	110-82-7	57.9	79.8
	庚烷(Heptane)	142-82-5	15.2	20.9
	异辛烷(Isooctane)	540-84-1	57.1	79.2
	苯(Benzene)	71-43-2	84	122
	甲苯(Toluene)	108-88-3	43.9	60.5
	二甲苯(Xylenes)	1330-20-7	51.5	68.2
醇类	甲醇(Methanol)	67-56-1	8.8	15.7
	乙醇(Ethanol)	64-17-5	4.1	7.2
	异丙醇(Isopropanol)	67-63-0	3.9	6.8
	庚醇(Heptanol)	111-70-6	22.9	28.6
	辛醇(Octanol)	111-87-5	38.3	45.7
	壬醇(Nonanol)	143-08-8	39.8	46.7
	苯甲醇(Benzyl alcohol)	100-51-6	45.2	55.1
醚类	乙醚(Diethyl ether)	60-29-7	8.7	16
	Methyl tert-butyl ether	1634-04-4	2.7	3.8
	四氢呋喃(Tetrahydrofuran)	109-99-9	9.1	14.9
醛类	糠醛(Furfural)	98-08-1	47.7	69.2
	苯甲醛(Benzaldehyde)	100-52-7	56.9	77.5
酮类	丙酮(Acetone)	67-64-1	1.5	2.6
有机酸类	甲酸(Formic acid)	64-18-6	25.8	43
	乙酸(Acetic acid)	64-19-7	1.3	2.1
	丙酸(Propionic acid)	79-19-4	27	41.2
酯类	乙酸乙酯(Ethyl acetate)	141-78-6	5	7.3
氯化烃类	二氯甲烷(Dichloromethane)	75-09-2	39.3	59.8
	氯仿(Chloroform)	67-66-3	70.7	103.8
	四氯化碳(Carbon tetrachloride)	56-23-5	80	109.7
	三氯乙烯(Trichloroethylene)	79-01-6	90.9	125.1
	四氯乙烯(Tetrachloroethylene)	127-18-4	82.7	107.7
	1.1.1-三氯乙烷(1.1.1-Trichloroethane)	71-55-6	34.7	49
	1.1.2.2-四氯乙烷(1.1.2.2-Tetrachloroethane)	79-34-5	76.9	97.3
	氯苯(Chlorobenzene)	108-90-7	58	75.9
其他试剂	乙腈(Acetonitrile)	75-05-8	18.8	26.8
	二硫化碳(Carbon disulphide)	75-15-0	61.6	89.6

序号	流动相的组成和消耗(括号内为消耗的体积，mL)		梯度数/次	流速/ (mL·min⁻¹)	运行时间/ min	参考文献	绿色度
序号	流动相的组成和消耗(括号内为消耗的体积，mL)		梯度数/次	流速/ (mL·min⁻¹)	运行时间/ min	参考文献	HPLC-EAT法	CHEMS-1法
Ⅰ	水(18.16)	乙腈(13.84)	3	0.8	40	[24]	49.5	370.9
Ⅱ	水(9)	乙腈(51)	1	1.5	40	[25]	182.4	1366
Ⅲ	二氯甲烷(9.67)	乙腈(14.09)	5	0.72	33	[26]	96.2	951.7
Ⅳ	磷酸水溶液(14.7)	乙腈(13.3)	7	1.0	28	[27]	47.6	365.4
Ⅴ	水(7.54)	甲醇(42.06)	6	0.8	62	[28]	88.9	660.3
Ⅵ	水(3.36)	甲醇(20.24)	5	0.8-1.0	29	[29]	42.8	317.8

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Introduction of the Concept of Greenness into Instrumental Analysis Course

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