一锅多组分反应选择性合成二芳基甲胺和三芳基甲烷——推荐一个有机化学综合实验

doi:10.3866/PKU.DXHX202401063

University Chemistry ›› 2024, Vol. 39 ›› Issue (8): 324-330.doi: 10.3866/PKU.DXHX202401063

• Chemistry Laboratory • Previous Articles Next Articles

Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions: Introduce a Comprehensive Experiment of Organic Chemistry

Yinuo Wang, Siran Wang, Yilong Zhao, Dazhen Xu

National Engineering Research Center of Pesticide (Tianjin), State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Received:2024-01-22 Revised:2024-04-25 Published:2024-08-08
Contact: Dazhen Xu E-mail:xudazhen@nankai.edu.cn

Abstract

Abstract: This article presents a comprehensive organic chemistry experiment in which salicylaldehyde, phenylboronic acid, and aromatic amines are employed as the substrates. The selective synthesis of diarylmethyl aniline and triarylmethane could be achieved through the control of substituents. The structure of the product is characterized by ¹H NMR and ¹³C NMR. This experiment combines theoretical knowledge to inspire students to think about mechanisms, helps them broaden their knowledge horizons, and establishes the concept of "green chemistry" and environmental awareness.

Key words: Multicomponent reactions, Aniline, Phenylboronic acid, Green chemistry

Yinuo Wang, Siran Wang, Yilong Zhao, Dazhen Xu. Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions: Introduce a Comprehensive Experiment of Organic Chemistry[J].University Chemistry, 2024, 39(8): 324-330.

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Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions: Introduce a Comprehensive Experiment of Organic Chemistry

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